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GraphPad StatMate
takes the guesswork out of evaluating how many data points you'll
need for an experiment, and makes it easy for you to quickly
calculate the power of an experiment to detect various hypothetical
differences. Its wizard-based format leads you through the necessary
steps to determine the tradeoffs in terms of risks and costs. There
is no learning curve with StatMate because it is self-explanatory.
All the documentation you need is built right into the program.

Why sample-size
matters
Many experiments and clinical trials are run with too few subjects.
An underpowered study is wasted effort if even substantial treatment
effects go undetected. When planning a study, therefore, you need to
choose an appropriate sample size. Your decision depends upon a
number of factors including, how scattered you expect your data to
be, how willing you are to risk mistakenly finding a difference by
chance, and how sure you must be that your study will detect a
difference, if it exists.
StatMate shows you the tradeoffs
Some programs ask how much statistical power you desire and how
large an effect you are looking for and then tell you what sample
size you should use. The problem with this approach is that often
you can't really know this in advance. You want to design a study
with very high power to detect very small effects and with a very
strict definition of statistical significance. But doing so requires
lots of subjects, more than you can afford. StatMate 2 shows you the
possibilities and helps you to understand the tradeoffs in terms of
risk and cost so you can make sound sample-size and power decisions.
What about power?
You also need to know if your completed experiments have enough
power. If an analysis results in a "statistically significant"
conclusion, it's pretty easy to interpret. But interpreting "not
statistically significant" results is more difficult. Its never
possible to prove that a treatment had zero effect, because tiny
differences may go undetected. StatMate shows you the power of your
experiment to detect various hypothetical differences.
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